Curriculum vitae

Amy M. (Hauser) Lyndaker, Ph.D.
Assistant Professor of Biology
Elmira College
Division of Mathematics and Natural Sciences
One Park Place • Elmira, NY 14901
Email: alyndaker@elmira.edu
Office phone: (607) 735-1940


Education

2009. Ph.D. in Biochemistry, Molecular and Cell Biology, Dept. of Molecular Biology and Genetics, Cornell University, Ithaca, NY
2003. B.A. with Honors in Biological Sciences and minor in Chemistry, Dept. of Biology, Goucher College, Baltimore, MD


Professional appointments

2015 – present. Assistant Professor of Biology, Elmira College, Div. of Mathematics and Natural Sciences
2013 – 2015. Postdoctoral Research Associate, Weiss laboratory, Cornell University, Dept. of Biomedical Sciences
2012 – 2013. Assistant Professor, Ithaca College, Dept. of Biology
2009 – 2012. Postdoctoral Research Fellow/Associate, Weiss laboratory, Cornell University, Dept. of Biomedical Sciences


Teaching experience
  • Assistant Professor of Biology at Elmira College, 2015 - present
  • Assistant Professor of Biology at Ithaca College, 2012 - 2013
  • Teaching Assistant, Cornell University, 2004; 2008; 2014; 2015
    • Dept. of Biomedical Sciences, College of Veterinary Medicine
    • Dept. of Molecular Biology and Genetics, College of Agriculture and Life Sciences
  • Laboratory mentor, Cornell University, 2005-2009; 2009-2012; 2013-2015
    • Weiss laboratory, Dept. of Biomedical Sciences
    •  Alani laboratory, Dept. of Molecular Biology and Genetics

Research experience

  • 2015 – present. Establishing the Lyndaker research laboratory, Elmira College, Elmira, NY
    • Investigating the molecular function and evolution of mammalian and fungal HUS1 and HUS1B DNA repair proteins using genetic studies in the baker’s yeast, S. cerevisiae
  • 2009 to 2012; 2013 to 2015. Laboratory of Dr. Robert S. Weiss, in collaboration with Dr. Paula E. Cohen, Cornell University, College of Veterinary Medicine, Dept. of Biomedical Sciences, Ithaca, NY
    • Postdoctoral work:
      • Determination of separable roles for subunits of the RAD9-RAD1-HUS1 (9-1-1) DNA damage checkpoint complex in maintaining genome integrity during mammalian meiosis
      • Evolutionary analysis of 9-1-1 subunits, paralogs, and interactors
      • Structure/function analysis of the HUS1 subunit of the 9-1-1 complex
      • Development of a novel mouse model of metastatic testicular cancer
      • Analysis of genome instability and the role of the DNA damage response in early germ cell tumorigenesis and in mediating treatment sensitivity in mouse models of testicular cancer
  • 2003 to 2009. Laboratory of Dr. Eric E. Alani, Cornell University, College of Agriculture and Life Sciences, Dept. of Molecular Biology and Genetics, Ithaca, NY
    • Ph.D. thesis work:
      • Investigation of the roles of DNA repair factors Rad1-Rad10-Slx4, Msh2-Msh6, and Sgs1 in gene conversion and heteroduplex rejection during homologous recombination in Saccharomyces cerevisiae
  • 2002 to 2003. Laboratory of Dr. Lesley R. Brown, Goucher College, Dept. of Chemistry, Baltimore, MD
    • Undergraduate Honors thesis work: Development of a plasmid-based in vivo assay for DNA mismatch repair in Escherichia coli
  • 2002 summer. Laboratory of Dr. Wu-Cheng (Winston) Shen, SUNY Upstate Medical University, Dept. of Biochemistry and Molecular Biology, Syracuse, NY
    • Summer undergraduate research fellow (SURF) work: Screening for transcriptional activators of the Pdr12 multi-drug transporter in Saccharomyces cerevisiae
  • 2001 summer. Laboratory of Dr. Leleng To Isaacs, Goucher College, Dept. of Biological Sciences, Baltimore, MD
    • Summer undergraduate research work: Comparative protein expression and analysis of Triclosan-resistant and wild-type Staphylococcus epidermidis

Publications

  • Chakraborty, U., C.M. George, A.M. Lyndaker, and E. Alani. 2016. “A delicate balance between repair and replication factors regulates recombination between divergent DNA sequences in Saccharomyces cerevisiae.” Genetics 202(2): 525-40.
  • Lim, P.X., D.R. Patel, K.E. Poisson, M. Basuita, C. Tsai, A.M. Lyndaker, B.J. Hwang, A.L. Lu, and R.S. Weiss. 2015. Genome protection by the 9-1-1 complex subunit HUS1 requires clamp formation, DNA contacts, and ATR signaling-independent effector functions. Journal of Biological Chemistry 290(24): 14826-40.
  • Lyndaker, A.M., A. Vasileva, D.J. Wolgemuth, R.S. Weiss, and H.B. Lieberman. 2013. “Clamping down on mammalian meiosis.” Cell Cycle 12(19): 3135-45.
  • Lyndaker, A.M., P.X. Lim, J.M. Mleczko, C.E. Diggins, J.K. Holloway, R.J. Holmes, R. Kan, D.H. Schlafer, R. Freire, P.E. Cohen, and R.S. Weiss. 2013. “Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance.” PLOS Genetics 9(2): e1003320.
  • Lyndaker, A.M., A.J. Modzelewski, and I.C. Welsh. 2012. “Reproductive and developmental genomics retreat at Cornell University, 2012.” Molecular Reproduction and Development 79(9): 588-91.
  • Balmus, G., M. Zhu, S. Mukherjee, A.M. Lyndaker, K.R. Hume, J. Lee, M.L. Riccio, A.P. Reeves, N.B. Sutter, D.M. Noden, R.M. Peters, and R.S. Weiss. 2012. “Disease severity in a mouse model of Ataxia Telangiectasia is modulated by the DNA damage checkpoint gene Hus1.” Human Molecular Genetics 21(15): 3408-20.
  • George, C.M., A.M. Lyndaker, and E. Alani. 2011. “The DNA damage checkpoint allows recombination between divergent DNA sequences in budding yeast.” DNA Repair 10(11): 1086-94.
  • Lyndaker, A.M., and E. Alani. 2009. “A tale of tails: Insights into the coordination of 3’ end processing during homologous recombination.” Bioessays 31(3): 315-21.
  • Lyndaker, A.M., T. Goldfarb, and E. Alani. 2008. “Mutants defective in Rad1-Rad10-Slx4 exhibit a unique pattern of viability during mating type switching in S. cerevisiae.” Genetics 179(4): 1807-21.

Honors

  • 2016, Jan. 31st. Member, Beta Beta Beta Biological Honor Society, Eta Sigma Chapter, Elmira College
  • 2012, June 14th-15th. First place, Best Oral Presentation Award, Reproductive and Developmental Genomics Retreat, Cornell University, Ithaca, NY
  • 2003, May. Honors in the Biological Sciences major, Goucher College
  • 2003. Member, Phi Beta Kappa Honor Society, Beta of Maryland chapter, Goucher College
  • 1999-2003. Dean’s Scholarship, Goucher College

Selected presentations

  • 2014, June 1-6th. “Distinct 9-1-1 clamps function to maintain genome integrity in the mammalian germ line” Poster. Meiosis Gordon Research Conference, New London, NH
  • 2013, October 4th. “Functions for distinct 9-1-1 complexes during mammalian meiosis.” Oral presentation. Cornell DNA Replication, Recombination, and Repair (R3) 10th Anniversary Symposium
  • 2012, May 24-25th. “Metastatic teratocarcinoma induction upon simultaneous Pten loss and Kras activation in postnatal murine germ cells.” Poster. NYSTEM 4th Annual Meeting, New York, NY
  • 2012, June 2-8th. “The DNA damage checkpoint protein HUS1 is required for efficient double-strand DNA break repair and XY body integrity during mammalian meiosis.” Poster. Meiosis Gordon Research Conference/Gordon Research Seminar, New London, NH
  • 2011, June. “Inactivation of Hus1 in the mouse testis results in meiotic defects, germ cell depletion, and infertility.” Poster. 5th Annual UB2020 Molecular Recognition in Biological Systems and Bioinformatics and 15th Annual DNA Replication and Repair Symposium, Roswell Park Cancer Institute, Buffalo, NY
  • 2010, October. “Genome instability and DNA damage signaling in 129-Dnd1Ter/Ter murine testicular teratomas.” Poster. Germ Cells meeting, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
  • 2008, June. “Mutants defective in Rad1-Rad10-Slx4 exhibit a unique pattern of viability during mating type switching in S. cerevisiae.” Poster. FASEB Yeast Chromosome Structure, Replication, and Segregation conference, Carefree, AZ
  • 2007, July-August. “Rad1-Rad10 authorizes efficient DSB repair during mating type switching in S. cerevisiae.” Poster. FASEB Genetic Recombination and Genome Rearrangements conference, Snowmass Village, CO
  • 2007, June “Rad1-Rad10 authorizes efficient DSB repair during mating type switching in S. cerevisiae.” Oral presentation. DNA Replication and Repair Symposium, SUNY at Buffalo, Buffalo, NY
  • 2007, April 21. “Rad1-Rad10 authorizes efficient DSB repair during mating type switching in S. cerevisiae.” Poster. Northeast Regional Yeast Meeting (NERY), SUNY Upstate Medical University, Syracuse, NY
  • 2006, June. “Evidence for partial repair during mating type switching in Saccharomyces cerevisiae.” Poster. DNA Replication and Repair Symposium, Roswell Park Cancer Institute, Buffalo, NY
  • 2005. “Roles for Msh2-Msh3 and Rad1-Rad10 during mating type switching in Saccharomyces cerevisiae.” Poster. Northeast Regional Yeast Meeting (NERY), Roswell Park Cancer Institute, Buffalo, NY
  • 2005, June. “Roles for Msh2-Msh3 and Rad1-Rad10 in 3’ nonhomologous tail removal during genetic recombination.” Oral presentation. DNA Replication and Repair Symposium, Roswell Park Cancer Institute, Buffalo, NY

Other professional activities

  • 2015 – present. Member, Genetics Society of America (GSA)
  • Manuscript reviewer for Nucleic Acids Research, PLOS Genetics, PLOS One, and various other peer-reviewed journals
  • 2012 June. Trainee organizer for the Reproductive and Developmental Genomics Retreat at Cornell University
  • Memberships at Cornell University:
    • DNA Replication, Recombination, and Repair (R3) group (2004-2015)
    • Stem Cell club (2009-2015)
    • Vertebrate Genomics club (VERGE; 2009-2015)

Volunteer work

  • 2015 April. Recruiter for Cornell University graduate programs in Biological and Biomedical Sciences (BBS) at the 29th Annual National Conference on Undergraduate Research (NCUR), Eastern Washington University, Spokane, WA
  • 2014-2015. Presenter and participant in the Cancer Resource Center of the Finger Lakes (CRCFL) monthly research seminar at Cornell University
  • 2006, 2007, 2008 April. Volunteer for Expanding Your Horizons (EYH) science, engineering, and mathematics day for girls at Cornell University
  • 2006 August. Demonstrator of DNA extraction with the Cornell Institute for Biology Teachers (CIBT) booth at the New York State Fair
  • 2005-2006. Participant in Graduate Student School Outreach Program (GSSOP)
  • 2005. Recruiter for Cornell University graduate programs in Molecular Biology and Genetics at the Annual Biomedical Research Conference for Minority Students (ABRCMS), Atlanta, Georgia
  • 2000-2002. Volunteer with Nursing Friends group interacting with the elderly in Baltimore area nursing homes
  • 2000-2001. Volunteer and pre-medical intern at St. Joseph Medical Center in Towson, MD